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Safe, Convenient ortho-Claisen Thermal Rearrangement Using a Flow Reactor
- Source :
- Organic Process Research & Development. 15:1428-1432
- Publication Year :
- 2011
- Publisher :
- American Chemical Society (ACS), 2011.
-
Abstract
- The [3,3] Claisen rearrangement is a well-known reaction that has been very useful for the synthesis of o-allyl phenols. The thermally induced rearrangement could present safety and operational issues at large batch scale. Herein, we report a process that utilized a tube reactor to make 80 g of an early phase intermediate in a short time while mitigating the potential chemistry hazards. Thus, both project material demands and flow chemistry proof of concept were achieved.
Details
- ISSN :
- 1520586X and 10836160
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Organic Process Research & Development
- Accession number :
- edsair.doi...........2b8f35bb334d375e207e83f3eb31146e