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Antidotal Effect of Vitamin E and C in the Management of Paraquat Intoxication in Rat

Authors :
Benjamin Nnamdi Okolonkwo
Ngozi Brisibe
Ibitoroko Maureen George-Opuda
Source :
Healthcare Studies. :24-29
Publication Year :
2023
Publisher :
ZenToks Technologies Services, 2023.

Abstract

The liver is an essential organ involved in anabolic and catabolic processes in the body. Substance like paraquat is injurious to the liver by way of oxidative damage. Vitamin E and C are known antioxidant used to tackle oxidative stress. The aim of this study was focused at evaluating the antidotal benefit of vitamin E and C in the treatment of paraquat intoxication in rat. Exactly 200 rats were obtained and grouped into four main groups (A, B, C and D) with each group having 50 rats. Except “A” group which was the control, all groups were treated with paraquat in doses of 0.02g, 0.04g and 0.06g respectively every 2 weeks for 3 months. All groups were subdivided into two groups designated as “0” and “VEC” amounting to a total of 8 subgroups. All subgroups with “VEC” designation were treated with 500mg of vitamin E and 2000mg/dl of vitamin C weekly for 3 months. Blood samples collected after treatment duration were via cardiac puncture and blood was assayed for liver enzyme activities. Results revealed that there was a significant increase (p-value

Details

Database :
OpenAIRE
Journal :
Healthcare Studies
Accession number :
edsair.doi...........2b1a7c0cb9a6d6c5a786f4142f68d779
Full Text :
https://doi.org/10.58612/hs113