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Antidotal Effect of Vitamin E and C in the Management of Paraquat Intoxication in Rat
- Source :
- Healthcare Studies. :24-29
- Publication Year :
- 2023
- Publisher :
- ZenToks Technologies Services, 2023.
-
Abstract
- The liver is an essential organ involved in anabolic and catabolic processes in the body. Substance like paraquat is injurious to the liver by way of oxidative damage. Vitamin E and C are known antioxidant used to tackle oxidative stress. The aim of this study was focused at evaluating the antidotal benefit of vitamin E and C in the treatment of paraquat intoxication in rat. Exactly 200 rats were obtained and grouped into four main groups (A, B, C and D) with each group having 50 rats. Except “A” group which was the control, all groups were treated with paraquat in doses of 0.02g, 0.04g and 0.06g respectively every 2 weeks for 3 months. All groups were subdivided into two groups designated as “0” and “VEC” amounting to a total of 8 subgroups. All subgroups with “VEC” designation were treated with 500mg of vitamin E and 2000mg/dl of vitamin C weekly for 3 months. Blood samples collected after treatment duration were via cardiac puncture and blood was assayed for liver enzyme activities. Results revealed that there was a significant increase (p-value
- Subjects :
- Cultural Studies
History
Literature and Literary Theory
Sociology and Political Science
Pharmaceutical Science
General Medicine
Plant Science
Horticulture
Agricultural and Biological Sciences (miscellaneous)
Otorhinolaryngology
Space and Planetary Science
Drug Discovery
General Earth and Planetary Sciences
Animal Science and Zoology
General Agricultural and Biological Sciences
Ecology, Evolution, Behavior and Systematics
General Environmental Science
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Healthcare Studies
- Accession number :
- edsair.doi...........2b1a7c0cb9a6d6c5a786f4142f68d779
- Full Text :
- https://doi.org/10.58612/hs113