Fatty Acids Corrupt Neutrophils in Cancer

Authors :: Max D. Wellenstein
Karin E. de Visser
Source :: Cancer Cell. 35:827-829
Publication Year :: 2019
Publisher :: Elsevier BV, 2019.
Abstract: Understanding how tumors escape from immune attack may offer novel therapeutic opportunities. Veglia et al. (2019) demonstrate in Nature that fatty acid transport protein 2 (FATP2) endows neutrophils with immunosuppressive capabilities that promote cancer growth. This receptor can be targeted to unleash anti-tumor immunity and to potentiate immune checkpoint blockade.