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ChemInform Abstract: Scalable Synthesis of the Potent HIV Inhibitor BMS-986001 by Non-enzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT)

Authors :
Tamas Benkovics
David R. Kronenthal
Jeffrey Nye
Gregory L. Beutner
Chris Sfouggatakis
Adrian Ortiz
Michael S. Bultman
Zhongping Shi
Source :
ChemInform. 46
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Title compound (IX*) is prepared from racemic lactol (I) using small-molecule-mediated dynamic kinetic resolution and a selective pyranose-to-furanose ring contraction as the key steps.

Details

ISSN :
09317597
Volume :
46
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi...........2a4e0847426642f0475aadbeac4a3d2d
Full Text :
https://doi.org/10.1002/chin.201542135