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Comparative Analysis of the Vaginal Microbiome Between women with Polycystic ovary syndrome and Healthy women: A Large-sample cross-sectional study

Authors :
Congcong Jin
Lang Qin
Zheng Liu
Xiao Li
Xuan Gao
Yongzhi Cao
Shigang Zhao
Jiaojiao Wang
Ting Han
lei yan
Jialun Song
Fangfang Zhang
Feifei Liu
Yousheng Zhang
Yuzhen Huang
Yuping Song
Yanjun Liu
Zhina Yao
Honglei Chen
Zhenzhen Zhang
Shengrui Zhao
Yuhan Feng
Yanan Zhang
Qian Yu
Tianyong Sun
Qing Feng
Han Zhao
Publication Year :
2022
Publisher :
Authorea, Inc., 2022.

Abstract

Objectives To investigate the vaginal microbiome (VMB) of a large sample size of polycystic ovary syndrome (PCOS) patients using 16S ribosomal RNA (16S rRNA) sequencing. Design A cross-sectional study Setting Ji Nan, China Sample A total of 1,446 subjects were recruited (PCOS, n=713, the controls, n=733). Methods Vaginal swabs were analyzed using 16S rRNA gene sequencing. Main outcome measures The microbiome diversity and composition of the PCOS group and control group were compared. In the PCOS prediction model, microbial interaction networks and functions prediction were investigated. Results The PCOS group had a higher alpha diversity in the VMB than controls (P

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........2a18998e5aef77e6a765f2448cf7de6e
Full Text :
https://doi.org/10.22541/au.166012206.67020917/v1