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Comparative Analysis of the Vaginal Microbiome Between women with Polycystic ovary syndrome and Healthy women: A Large-sample cross-sectional study
- Publication Year :
- 2022
- Publisher :
- Authorea, Inc., 2022.
-
Abstract
- Objectives To investigate the vaginal microbiome (VMB) of a large sample size of polycystic ovary syndrome (PCOS) patients using 16S ribosomal RNA (16S rRNA) sequencing. Design A cross-sectional study Setting Ji Nan, China Sample A total of 1,446 subjects were recruited (PCOS, n=713, the controls, n=733). Methods Vaginal swabs were analyzed using 16S rRNA gene sequencing. Main outcome measures The microbiome diversity and composition of the PCOS group and control group were compared. In the PCOS prediction model, microbial interaction networks and functions prediction were investigated. Results The PCOS group had a higher alpha diversity in the VMB than controls (P
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........2a18998e5aef77e6a765f2448cf7de6e
- Full Text :
- https://doi.org/10.22541/au.166012206.67020917/v1