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<scp> T 1 </scp> Mapping on <scp>Gd‐EOB‐DTPA</scp> ‐Enhanced <scp>MRI</scp> for the Prediction of Oxaliplatin‐Induced Liver Injury in a Mouse Model
- Source :
- Journal of Magnetic Resonance Imaging. 53:896-902
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- BACKGROUND Oxaliplatin-induced liver injury (OILI) not only impairs hepatic regeneration but also increases postoperative morbidity and mortality. Therefore, noninvasive, accurate, and early diagnosis of OILI is mandatory. PURPOSE To evaluate the potential of T1 mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for assessing OILI in a mouse model. STUDY TYPE Case control, animal model. ANIMAL MODEL Thirty oxaliplatin-treated mice and 10 control mice were included. FIELD STRENGTH Volumetric interpolated breath-hold examination sequence: 3T scanner with a phased-array animal 8-channel coil. T1 mapping before and at hepatobiliary phase (HBP) after injection of Gd-EOB-DTPA were undertaken. ASSESSMENT T1 relaxation times of the liver parenchyma were measured and the reduction rate (ΔT1 %) was calculated. Histological findings were used as a standard reference. STATISTICAL TESTS The Kruskal-Wallis test with pairwise comparisons using the Mann-Whitney U-test were applied to compare the parameters across groups. Spearman's rank correlation test and receiver operating characteristics (ROC) analyses were performed. Areas under the curves (AUCs) were compared using the DeLong method. RESULTS Histologically, mice were classified as normal (n = 10), hepatocellular degeneration without fibrosis (n = 16), and hepatocellular degeneration with fibrosis (n = 14). HBP T1 relaxation time increased with the severity of OILI (rho = 0.60, P
- Subjects :
- Liver injury
medicine.medical_specialty
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Gadolinium
Urology
chemistry.chemical_element
Magnetic resonance imaging
medicine.disease
030218 nuclear medicine & medical imaging
Oxaliplatin
03 medical and health sciences
0302 clinical medicine
chemistry
Fibrosis
medicine
Radiology, Nuclear Medicine and imaging
Stage (cooking)
business
medicine.drug
Rank correlation
Subjects
Details
- ISSN :
- 15222586 and 10531807
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Journal of Magnetic Resonance Imaging
- Accession number :
- edsair.doi...........29e62e583d6c4864aff2ae48b450e355