A phase I/II study of oncolytic reovirus plus carboplatin/paclitaxel in patients with advanced solid cancers with emphasis on squamous cell carcinoma of the head and neck (SCCHN)

Authors :: K. Mettinger
Kevin J. Harrington
George M. Gill
M. Coffey
Eleni M. Karapanagiotou
Hardev Pandha
John D. Chester
Source :: Journal of Clinical Oncology. 28:3080-3080
Publication Year :: 2010
Publisher :: American Society of Clinical Oncology (ASCO), 2010.
Abstract: 3080 Background: Reolysin is an isolate of reovirus, a RNA virus which replicates in cells with activated Ras signaling pathway while sparing normal cells. We conducted a phase I/II dose escalation...

Subjects :: Oncology
Cancer Research
medicine.medical_specialty
integumentary system
biology
business.industry
viruses
RNA virus
biology.organism_classification
Carboplatin/paclitaxel
Oncolytic virus
Ras Signaling Pathway
Internal medicine
Reolysin
medicine
Basal cell
In patient
Head and neck
business

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