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Fabrication and compressive strength of porous hydroxyapatite scaffolds with a functionally graded core/shell structure
- Source :
- Journal of the European Ceramic Society. 31:13-18
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- A novel type of porous hydroxyapatite (HA) scaffolds with a functionally graded core/shell structure was fabricated by freeze casting HA/camphene slurries with various HA contents into fugitive molds containing a graphite template with three-dimensionally interconnected pores for the creation of a highly porous core. All the fabricated samples had functionally graded core/shell structures with 3-D periodic pore networks in a core surrounded by a relatively dense shell. The overall porosity of the sample decreased from 60 to 38 vol% with increasing HA content in the HA/camphene slurry from 20 to 36 vol% due to a decrease in porosity in both the core and shell regions. In addition, the compressive strength was improved remarkably from 12 ± 1.1 to 32 ± 3.0 MPa. The in vitro cell test using a pre-osteoblast cell line showed that the samples had good biocompatibility.
Details
- ISSN :
- 09552219
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of the European Ceramic Society
- Accession number :
- edsair.doi...........296267bcdfe13be7a34fc6b212a4225e