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Comparison of mortality risk: a score for very low birthweight infants Commentary
- Source :
- Archives of Disease in Childhood - Fetal and Neonatal Edition. 76:F146-F151
- Publication Year :
- 1997
- Publisher :
- BMJ, 1997.
-
Abstract
- AIM To develop and evaluate a score which quantifies mortality risk in very low birthweight (VLBW) infants (birthweight below 1500 g) at admission to the neonatal intensive care unit. METHODS Five hundred and seventy two VLBW infants admitted from 1978 to 1987 were randomly assigned to a cohort (n = 396) for score development and a cohort (n = 176) for score validation. Two hundred and ninety four VLBW infants admitted from 1988 to 1991 were used to compare risk adjusted mortality between the two eras. RESULTS Using multiple regression analysis, birthweight, Apgar score at 5 minutes, base excess at admission, severity of respiratory distress syndrome, and artificial ventilation were predictive of death in the development cohort. According to regression coefficients, a score ranging from 3 to 40 was developed. At a cutoff of 21, it predicted death in the validation cohort with a sensitivity of 0.85, a specificity of 0.73, and a correct classification rate of 0.76. The area under the receiver operating characteristic curve was 0.86. There was no significant difference in risk severity and in risk adjusted mortality between the eras 1978–87 and 1988–91. CONCLUSION The present score is robust, easily obtainable at admission, and permits early randomisation based on mortality risk.
- Subjects :
- Pediatrics
medicine.medical_specialty
Neonatal intensive care unit
Receiver operating characteristic
business.industry
Birth weight
Obstetrics and Gynecology
General Medicine
Infant mortality
Predictive value of tests
Pediatrics, Perinatology and Child Health
Cohort
Medicine
Apgar score
business
Cohort study
Subjects
Details
- ISSN :
- 14682052 and 13592998
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Accession number :
- edsair.doi...........29158c7bf6a4ad9ca25b4669753717f0