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Selective Solid-Phase Extraction of Sulfonamides from Edible Swine Tissues Using High-Performance Imprinted Polymers
- Source :
- Food Analytical Methods. 13:1304-1313
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- In the present study, sulfamethazine-imprinted polymers have been prepared by bulk polymerization method with a living radical photopolymerization using sulfamethazine (SM2) as the template molecule, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, and azobisisobutyronitrile (AIBN) as the initiator in the porogenic solvent of acetonitrile. After estimating the recognition properties, the imprinting factor of the polymer reached up to 9.3779. Then, the polymer particles were incorporated into a solid-phase extraction (SPE) column for the selective separation and purification of the sulfonamides (SAs), including sulfadiazine (SD), sulfamerazine (SM1), and SM2, from edible swine tissues. By using the detection method of high-performance liquid chromatography with the optimum SPE conditions, the limits of detection and limits of quantitation were calculated as 0.7–2.3 μg kg−1 and 3.4–4.6 μg kg−1 in the complex samples, respectively. The recovery of SAs ranged from 85.5 to 88.3%. Compared with the commonly used Waters Oasis HLB® column, the proposed selective SM2-MI-SPE column has opened a promising new approach for trace enrichment of the residues. It will facilitate sulfonamide residue analysis in animal tissues.
- Subjects :
- Sulfamerazine
Chromatography
Bulk polymerization
Ethylene glycol dimethacrylate
010401 analytical chemistry
Extraction (chemistry)
Azobisisobutyronitrile
04 agricultural and veterinary sciences
040401 food science
01 natural sciences
Applied Microbiology and Biotechnology
0104 chemical sciences
Analytical Chemistry
chemistry.chemical_compound
0404 agricultural biotechnology
Photopolymer
Methacrylic acid
chemistry
medicine
Solid phase extraction
Safety, Risk, Reliability and Quality
Safety Research
Food Science
medicine.drug
Subjects
Details
- ISSN :
- 1936976X and 19369751
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Food Analytical Methods
- Accession number :
- edsair.doi...........290af8d280cf4ca00a4fa033baa7cb0f