Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-phenylquinazolin-4-ylamino) (phenyl) methyl phosphate

A convenient and efficient one-pot reaction has been employed for the synthesis of new aaminophosphonates 4a-4l via Kabachnik-Fields reaction in 89-95 % yields. In the procedure developed, equimolar quantities of 2phenylquinazoline-4-amine 1, various aromatic aldehydes 2a-2l and triethyl phosphite 3 was carried out under solvent-free conditions using Alum (KAl (SO4)2.12H2O). The products were characterized by IR, 1 H and 13 C spectra and elemental analysis. All the synthesized compounds were screened for in vitro antibacterial activity (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium) and antifungal activity (Candida albicans, Aspergillus niger).