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Brønsted Acid Catalyzed Domino Aza-Piancatelli Rearrangement/Michael Reaction: Construction of 1,4-Benzodiazepin-5-ones in One Pot
- Source :
- European Journal of Organic Chemistry. 2017:5671-5678
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- A pTSA catalyzed domino aza-Piancatelli rearrangement/Michael reaction was developed for the construction of 1,4-benzodiazepin-5-ones in one pot. The methodological studies offer broad scope and proceed well with various furfuryl carbinols as well as o-aminobenzamides giving medicinally relevant new chemical entities.
Details
- ISSN :
- 1434193X
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- European Journal of Organic Chemistry
- Accession number :
- edsair.doi...........28c512dd27e05d0e849395d828c7691b