Differential Effects of Hydrophilic versus Lipophilic Statins on RhoA Kinase Inhibition and Membrane Stability in Cardiac Myocytes

Authors :: Alice E. Zemljic-Harpf
Elizabeth Asfaw
Joseph C. Godoy
Jan M. Schilling
Erika A. Alvarez
Anna Schwarz
Hemal H. Patel
Nancy D. Dalton
Source :: The FASEB Journal. 29
Publication Year :: 2015
Publisher :: Wiley, 2015.
Abstract: Statins are among the most prescribed drugs worldwide. By inhibiting mevalonate synthesis statins inhibit protein prenylation and thereby may reduce RhoA kinase activity. Cardiac overexpression of ...

Subjects :: RHOA
biology
Chemistry
nutritional and metabolic diseases
Kinase inhibition
Biochemistry
Differential effects
Cell biology
Membrane
Genetics
biology.protein
Protein prenylation
Myocyte
lipids (amino acids, peptides, and proteins)
cardiovascular diseases
Kinase activity
Prescribed drugs
Molecular Biology
Biotechnology

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