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Immunomodulatory Effects of Antipsychotic Drugs in Whole Blood Cell Cultures from Healthy Subjects
- Source :
- Current Psychiatry Research and Reviews. 15:261-266
- Publication Year :
- 2020
- Publisher :
- Bentham Science Publishers Ltd., 2020.
-
Abstract
- Objective:We aimed to evaluate the effects of various antipsychotics on the in vitro production of C-reactive protein (CRP) in whole blood cell cultures from healthy volunteers. The evaluation was performed using haloperidol, quetiapine, clozapine, amisulpride, and chlorpromazine.Methods:Antipsychotic agents were added to the participants' whole blood samples, and the resulting CRP levels were measured. For each agent, three different concentrations were tested: the therapeutic concentration, one-tenth the therapeutic concentration, and ten times the therapeutic concentration. The differences in CRP concentrations before and after drug administration were investigated.Results:The Friedman test showed that haloperidol, amisulpride, and chlorpromazine significantly increased CRP levels in the blood culture samples; however, clozapine and quetiapine did not increase CRP levels. In the case of chlorpromazine, elevated CRP levels were noted at all concentrations tested.Conclusion:Our study suggests that some antipsychotics elevate CRP levels in vitro. These results agree with previous studies showing that antipsychotics have immunomodulatory effects. Future research will clarify our findings and our understanding of antipsychotic drugs and their impact on immune regulation.
- Subjects :
- 0301 basic medicine
biology
business.industry
medicine.medical_treatment
C-reactive protein
Healthy subjects
Immune regulation
Inflammation
medicine.disease
03 medical and health sciences
Psychiatry and Mental health
030104 developmental biology
0302 clinical medicine
Cell culture
Schizophrenia
Immunology
biology.protein
Medicine
medicine.symptom
business
Antipsychotic
030217 neurology & neurosurgery
Whole blood
Subjects
Details
- ISSN :
- 26660822
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Current Psychiatry Research and Reviews
- Accession number :
- edsair.doi...........27a9038ff87c7f6d561feb7080a4d1c8