Design, synthesis, and properties of novel water-soluble cyclophanes having naphthylphenylmethane units as hosts for aliphatic and aromatic guests

Authors :: Kazunori Odashima
Osamu Yoshino
Kenji Koga
Hajime Kawakami
Source :: Chemical and Pharmaceutical Bulletin. 33:5610-5613
Publication Year :: 1985
Publisher :: Pharmaceutical Society of Japan, 1985.
Abstract: Novel water-soluble cyclophanes (2a, 2b) which act as hosts having hydrophobic cavities were made by connecting two naphthylphenylmethane units and two tetramethylene bridges via four nitrogens. 1H NMR spectral studies have shown that in water these cyclophanes form inclusion complexes with aliphatic as well as aromatic guests.

Subjects :: Chemistry
Diol
General Chemistry
General Medicine
Nuclear magnetic resonance spectroscopy
Inclusion compound
chemistry.chemical_compound
Sulfonate
Stability constants of complexes
Drug Discovery
Proton NMR
Organic chemistry
Carboxylate
Cyclophane

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