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ChemInform Abstract: Synthesis of Some New Thieno(2,3-b)(1,6)naphthyridines and Related Compounds
- Source :
- ChemInform. 25
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- 3,5-Dibenzylidene-1-isopropy1-4-piperidinone (1) reacts with cyanothioacetamide to give 1,6-naphthyridine-2(1H) thione derivative 2. Reaction of 2 with halo ketones or halo esters followed by ring closure gives thieno[2,3-b][1,6]naphthyridine derivatives 5a—i, which are used as versatile intermediates in the synthesis of related heterocyclic ring systems as pyrimidothienonaphthyridines 10, 11, 14, and 15, oxazinothienonaphthyridine (13) and triazinothienonaphthyridine (9).
Details
- ISSN :
- 09317597
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........276fc7436d97a1de19e93e65b079913e