Notes on the unusual course in certain cases of migraine

Two of seven cases of migraine out of a series slightly in excess of 100 are reported in detail, because the episodic attacks in these seven cases have been replaced in the fourth or fifth decade by a continuous, low grade cephalalgia. The pathophysiological origin is not clear; but it is possible that a functional, long-lasting vasoconstrictor neurosis slowly effects organic changes in the vessels or in the adjacent brain tissue.