Metallic Glutamates in Nutritional Anemia

Our knowledge of some of the many aspects of the problem of anemia has been enlarged recently by studies on the milk anemia of the rat. Thus from the work of the Wisconsin investigators the importance of Cu in Hb regeneration is now generally appreciated. Cu therapy, however, does not present any particular difficulty, while Fe deficiencies and Fe therapy still remain important problems in the clinic. For such investigations milk anemia is a convenient experimental approach. Although much work has been done there is still some uncertainty regarding the response of anemic rats to small doses of Fe.1, 2 Certain investigators3, 4 have reported that glutamic acid supplements Fe in nutritional anemia, but this has not been confirmed by others.5The following experiments were carried out with about 300 rats in order to clarify some of the discrepancies in regard to the effect of Fe in anemia and to determine whether glutamic acid could be employed as an effective vehicle for the administration of minerals in sec...