FADS1 overexpression promotes fatty acid synthesis and triacylglycerol accumulation via inhibiting the AMPK/SREBP1 pathway in goat mammary epithelial cells

Authors :: Jiangtao Huang
Yuexin Shao
Xueyang Zong
Huawen Zhang
Xian Zhang
Zhifei Zhang
Huaiping Shi
Source :: Food & Function. 13:5870-5882
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: During lactation, FADS1 is up-regulated, then inhibits the phosphorylation of AMPK. The downregulation of p-AMPK promotes SREBP1 nuclear translocation, and induces SREBP1 target gene FASN and ACC expression in GMEC, leading to increased lipogenesis.

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