Clinical Efficacy of Probiotics for Oral Health: A Systematic Review of Clinical Trials Running title: Probiotics and oral health

Introduction: The aim of the present study was to review the clinical efficacy of probiotics for oral health in randomized controlled trials. Method: An electronic search was conducted in December 2020 in Embase, Medline, The Cochrane Library, ProQuest, and Google Scholar using the following keywords: “mouthwash” and “probiotics”.The titles and abstracts of 3,775 articles were screened and 24 publications that fulfilled the inclusion criteria were included. Result: A total of 24 clinical trials were reviewed, including 1612 participants receiving either probiotics or mouth treatments. The results of this review indicated that individuals receiving probiotic products have a significant reduction (65% reduction; p Conclusion: Probiotics are considered a safe alternative to conventional therapies, such as chlorhexidine and fluoride. Co-administration of chlorhexidine, fluoride, and probiotics seems to be a perfect package.