Back to Search
Start Over
Spirulina platensis ameliorative effect against GSM 900-MHz cellular phone radiation-induced genotoxicity in male Sprague-Dawley rats
- Source :
- Comparative Clinical Pathology. 23:1719-1726
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The current study was set to explore the possible radioprotective activity of Spirulina platensis (SP) against some genotoxic effects of GSM 900-MHz cellular phone radiation on both bone marrow cells and erythrogram. Sixty adult male Sprague-Dawley rats were divided into four groups, exposed to mobile phone radiation for 6 h/day and/or orally administered 300 mg SP/kg body wt for 30 days. Erythrogram elements, alkaline comet, and micronucleus assays for the detection of DNA damage were estimated besides a histopathological examination of bone marrow tissue. Mobile phone radiation exposure evoked a significant increase in RBC count, Hb concentrations, and packed cell volume (PCV) in addition to marked elevation in the frequencies of micronucleated polychromatic erythrocytes in the peripheral blood and bone marrow compared to control. On the other hand, SP significantly reduced the level of DNA damage and oxidative stress resulted from electromagnetic phone’s radiations. Conclusively, the continuous exposure to mobile phone’s radiation for a long time had a significant adverse genotoxic effect on both bone marrow and hematopoietic system. Yet, SP is proved to be a useful candidate compound in radioprotection.
- Subjects :
- medicine.medical_specialty
Hematology
DNA damage
Pharmacology
Biology
medicine.disease_cause
Pathology and Forensic Medicine
Toxicology
Haematopoiesis
medicine.anatomical_structure
Mobile phone radiation and health
Internal medicine
medicine
Bone marrow
Anatomy
Micronucleus
Oxidative stress
Genotoxicity
Subjects
Details
- ISSN :
- 1618565X and 16185641
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Comparative Clinical Pathology
- Accession number :
- edsair.doi...........25d01abc37fcbc0fd1df9bb368ad029c