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Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
- Source :
- Nature Medicine. 16:324-328
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Vaccine design is challenging when the infectious agent is genetically diverse. Polyvalent 'mosaic' antigens might be used to address this challenge, and these two studies show promising results in monkeys infected with HIV-1.
- Subjects :
- 0303 health sciences
Human immunodeficiency virus (HIV)
Mosaic (geodemography)
General Medicine
Biology
medicine.disease_cause
Virology
General Biochemistry, Genetics and Molecular Biology
3. Good health
03 medical and health sciences
0302 clinical medicine
Immune system
Cd8 t lymphocyte
Antigen
Immunology
medicine
030212 general & internal medicine
030304 developmental biology
Infectious agent
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi...........2576f380d96b6776bfa8b35f458b84fd
- Full Text :
- https://doi.org/10.1038/nm.2108