Back to Search Start Over

Participation of Neuropeptides in Antigen-Induced Contraction of Guinea Pig Bronchi via NK2 but Not NK1 Receptor Stimulation

Authors :
Kiyoshi Yasui
Shigekatsu Kohno
Takashi Tanpo
Toshihisa Kamiki
Takeshi Nabe
Source :
Pharmacology. 60:169-174
Publication Year :
2000
Publisher :
S. Karger AG, 2000.

Abstract

We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK1 and NK2 receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotriene antagonist. SR-48968 but not CP-96345, significantly inhibited the late phase of the bronchial contraction. Phosphoramidon, a neutral endopeptidase inhibitor, tended to potentiate bronchial contraction. Posttreatment with SR-48968 decreased the enhanced contraction induced by the inhibitor as well as the nonenhanced contraction to similar levels of tension. On the other hand, antigen-induced tracheal contraction was not altered by either neuropeptide antagonist. These results suggest that neuropeptides mediate the antigen-induced contractile response of the guinea pig bronchus partly through NK2 receptor stimulation.

Details

ISSN :
14230313 and 00317012
Volume :
60
Database :
OpenAIRE
Journal :
Pharmacology
Accession number :
edsair.doi...........255a603f9879fd2ad291dd5aab2dc406
Full Text :
https://doi.org/10.1159/000028365