Back to Search
Start Over
Participation of Neuropeptides in Antigen-Induced Contraction of Guinea Pig Bronchi via NK2 but Not NK1 Receptor Stimulation
- Source :
- Pharmacology. 60:169-174
- Publication Year :
- 2000
- Publisher :
- S. Karger AG, 2000.
-
Abstract
- We evaluated the contribution of neuropeptides to antigen-induced contractions of isolated bronchi and tracheae of passively sensitized guinea pigs using CP-96345 and SR 48968, specific antagonists of NK1 and NK2 receptors, respectively, in combination with treatment by an antihistaminic and a cysteinyl leukotriene antagonist. SR-48968 but not CP-96345, significantly inhibited the late phase of the bronchial contraction. Phosphoramidon, a neutral endopeptidase inhibitor, tended to potentiate bronchial contraction. Posttreatment with SR-48968 decreased the enhanced contraction induced by the inhibitor as well as the nonenhanced contraction to similar levels of tension. On the other hand, antigen-induced tracheal contraction was not altered by either neuropeptide antagonist. These results suggest that neuropeptides mediate the antigen-induced contractile response of the guinea pig bronchus partly through NK2 receptor stimulation.
Details
- ISSN :
- 14230313 and 00317012
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Pharmacology
- Accession number :
- edsair.doi...........255a603f9879fd2ad291dd5aab2dc406
- Full Text :
- https://doi.org/10.1159/000028365