The Unfolded Protein Response in Mouse Cerebral Cortex

The unfolded protein response (UPR) is important for normal cellular homeostasis, development, and physiology. Endoplasmic reticulum stress and the UPR have also been implicated in a variety of diseases and pathologies. Thus the UPR is being studied in many model systems. We describe in this chapter methods for studying the UPR in a mouse model, specifically the cerebral cortex of mouse brain.