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BIOCHEMICAL MARKERS OF CARDIAC INJURY IN NORMAL AND SURVIVING VERSUS NON-SURVIVING SEPTICEMIC NEONATAL FOALS
- Source :
- Journal of Veterinary Emergency and Critical Care. 14:S1-S17
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- Although myocardial injury can be a significant component of multiple organ dysfunction (MODS) in association with septicemia in critically ill human patients, it is as yet an undefined clinical entity in equine septicemia. With septicemia as the leading cause of death in neonatal foals, a better understanding of the pathophysiology, diagnosis and treatment of MODS will be important in further improving survival rates. We designed a prospective study to establish normal ranges for cardiac troponin I (cTnI), T (cTnT) and CKMB mass in healthy 24–48 hour old foals, as well as septicemic neonatal foals seen over a 2-year period in a teaching hospital. We also performed a comparison of these biomarkers in surviving and non-surviving septicemic foals. Sepsis was judged on the basis of the presence of any of the 3 following criteria: blood culture positive at admission, admission sepsis score ≥11, or 3 or more sites of infection during hospitalization in foals ≤14 days of age. cTnI was measured by the ACCESS® (Beckman Coulter), cTnT was measured using the Elecsys 2010® Immunoassay (Roche), and CKMB mass measurements were performed using the Elecsys 2010®. Each parameter was described using range and 95th and 50th percentile. Comparisons were made for each parameter between normal and septic foals as well as surviving and non-surviving septic foals using the non-parametric Wilcoxon's rank sum test. Significance was set at p
- Subjects :
- medicine.medical_specialty
education.field_of_study
General Veterinary
biology
business.industry
animal diseases
Organ dysfunction
Population
medicine.disease
digestive system
Surgery
Sepsis
Troponin complex
Foal
Internal medicine
biology.animal
parasitic diseases
Troponin I
medicine
medicine.symptom
business
Prospective cohort study
education
Cause of death
Subjects
Details
- ISSN :
- 14764431 and 14793261
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Emergency and Critical Care
- Accession number :
- edsair.doi...........252f01505fa7875f5a08af2b398ea4d6