Kilogram-Scale Asymmetric Ruthenium-Catalyzed Hydrogenation of a Tetrasubstituted Fluoroenamide

Authors :: Michael Welch
Erhard Bappert
Srinivasan Babu
Felix Spindler
Andreas Stumpf
Daniel P. Sutherlin
John Gaudino
Mark Reynolds
Source :: Advanced Synthesis & Catalysis. 353:3367-3372
Publication Year :: 2011
Publisher :: Wiley, 2011.
Abstract: Ruthenium-catalyzed asymmetric homogeneous hydrogenation (AHH) is used as the key step of a multi-kilogram scale synthesis of an enantiomeric fluoropiperidine. The AHH of a tetrasubstituted β-fluoroenamide is carried out under mild conditions using a Ru/Josiphos catalyst with high ee (98%).

Subjects :: chemistry
Homogeneous
Fluorine
chemistry.chemical_element
Organic chemistry
Homogeneous catalysis
General Chemistry
Enantiomer
Catalysis
Ruthenium

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