What makes SGLT2 inhibition so effective in lowering blood glucose in diabetes? (689.5)

Authors :: Michael Rose
Takahiro Masuda
Maria Gerasimova
Timo Rieg
Scott C. Thomson
Volker Vallon
Eric Mayoux
Hermann Koepsell
Source :: The FASEB Journal. 28
Publication Year :: 2014
Publisher :: Wiley, 2014.
Abstract: Studies in knockout mice indicated that, in euglycemia, the sodium glucose cotransporters SGLT2 and SGLT1 reabsorb 97 and 3% of filtered glucose, respectively. The SGLT1 contribution is enhanced to...

Subjects :: endocrine system
medicine.medical_specialty
urogenital system
Chemistry
digestive, oral, and skin physiology
medicine.disease
Biochemistry
Sodium Glucose Cotransporters
Endocrinology
Diabetes mellitus
Internal medicine
Knockout mouse
Genetics
medicine
Molecular Biology
hormones, hormone substitutes, and hormone antagonists
Biotechnology

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