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Caffeic Acid Derivatives from Bacopa monniera Plants as Inhibitors of Pancreatic Lipase Activity and their Structural Requirements
- Source :
- Natural Product Communications. 11:1934578X1601101
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- The methanol extract of whole Bacopa monniera plants inhibited pancreatic lipase activity in vitro. From this extract we have reported the isolation of 11 triterpene glycosides and 5 phenylethanoid- and/or phenylpropanoid- glycosides. In this paper, we describe the effects of the methanol extract and/or its constituents on pancreatic lipase activity and the isolation of an active constituent, desrhamnosyl isoacteoside. In addition, the structural requirements for its inhibitory effects were examined. We also examined the effects on the elevation of plasma triglyceride (TG) levels in olive oil loaded mice. The major active constituents, desrhamnosyl isoacteoside and plantainoside B, reduced plasma TG levels in the mice. The inhibitory effects of B. monniera and its constituents on pancreatic lipase activity and plasma TG level are reported for the first time.
- Subjects :
- Pharmacology
chemistry.chemical_classification
biology
Phenylpropanoid
010405 organic chemistry
Glycoside
Plant Science
General Medicine
Phenylethanoid
biology.organism_classification
01 natural sciences
In vitro
Bacopa
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Complementary and alternative medicine
chemistry
Triterpene
Biochemistry
Drug Discovery
Caffeic acid
Methanol
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........245fa3ef0fb85ba4ccda4f78a492b2ec