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Could the spanning of NAM-AD subsites by poly (ADP ribose) polymerase inhibitors potentiate their selective inhibitory activity in breast cancer treatment? Insight from biophysical computations
- Source :
- Molecular Simulation. 48:131-139
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Poly (ADP-ribose) polymerase (PARP) inhibition by pharmacological agents has been a useful cancer treatment in recent times. PARP inhibitors represent a category of anticancer drugs that function b...
- Subjects :
- biology
Chemistry
General Chemical Engineering
Poly ADP ribose polymerase
General Chemistry
Selective inhibition
Condensed Matter Physics
medicine.disease
Inhibitory postsynaptic potential
Poly (ADP-Ribose) Polymerase Inhibitor
Cancer treatment
Breast cancer
Modeling and Simulation
medicine
biology.protein
Cancer research
General Materials Science
Polymerase
Function (biology)
Information Systems
Subjects
Details
- ISSN :
- 10290435 and 08927022
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Molecular Simulation
- Accession number :
- edsair.doi...........24388c094eb587541ebb06a87a39b362