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Response to Comment on 'DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification'
- Source :
- Science. 361
- Publication Year :
- 2018
- Publisher :
- American Association for the Advancement of Science (AAAS), 2018.
-
Abstract
- Following the Comment of Stewart et al ., we repeated our analysis on sequencing runs from The Cancer Genome Atlas (TCGA) using their suggested parameters. We found signs of oxidative damage in all sequence contexts and irrespective of the sequencing date, reaffirming that DNA damage affects mutation-calling pipelines in their ability to accurately identify somatic variations.
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 361
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi...........24150534f038462093036ec9a843c040