Accuracy improvement of nuclear position extraction from hepatic histopathologic images

In the field of histopathologic diagnosis, differential diagnosis of borderline lesions is a serious problem. For example, differential diagnosis between early well-differentiated hepatocellular carcinoma (ewHCC) and noncancer is difficult because the cellular atypism of ewHCC is very low. Nuclear density (number of nuclei per unit area) is one of the most important features in differential diagnosis between non-cancer and ewHCC.