Transosseous application of low-intensity ultrasound at the tendon-bone interface affects the healing rate and up-regulates simultaneously the expression of collagen type I and tRNAGly

The present study investigates the effect of transosseous low-intensity pulsed ultrasound (LiUS) during lingamentization process on the healing at tendon graft-bone interface in rabbits. Analysis of the RT-PCR products showed statistically significant up-regulation of genes encoding collagen type I and tRNAGly in the study group compared to the control group. Histological examination indicated a faster healing rate and a more efficient lingamentization process after ultrasound treatment. Our results suggest that transosseous application of LiUS enhances the healing rate of the tendon graft-bone interface, possibly by affecting the expression levels of significant genes.