Back to Search
Start Over
IL-21 Is a Double-Edged Sword in the Systemic Lupus Erythematosus–like Disease of BXSB.Yaa Mice
- Source :
- The Journal of Immunology. 191:4581-4588
- Publication Year :
- 2013
- Publisher :
- The American Association of Immunologists, 2013.
-
Abstract
- The pleiotropic cytokine IL-21 is implicated in the pathogenesis of human systemic lupus erythematosus by polymorphisms in the molecule and its receptor (IL-21R). The systemic lupus erythematosus-like autoimmune disease of BXSB.Yaa mice is critically dependent on IL-21 signaling, providing a model for understanding IL-21/IL-21R signaling in lupus pathogenesis. In this study, we generated BXSB.Yaa mice selectively deficient in IL-21R on B cells, on all T cells, or on CD8+ T cells alone and examined the effects on disease. We found that IL-21 signaling to B cells is essential for the development of all classical disease manifestations, but that IL-21 signaling also supports the expansion of central memory, CD8+ suppressor cells and broadly represses the cytokine activity of CD4+ T cells. These results indicate that IL-21 has both disease-promoting and disease-suppressive effects in the autoimmune disease of BXSB.Yaa mice.
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 191
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi...........234e7fa67cdc1ac8be0e0f9c7d272442