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Metal-Free Synthesis of 1,3-Dioxane Derivatives from Aromatic Alkynes and Paraformaldehyde
- Source :
- Synlett. 33:959-964
- Publication Year :
- 2022
- Publisher :
- Georg Thieme Verlag KG, 2022.
-
Abstract
- Here we report the efficient synthesis of a series of 1,3-dioxane derivatives from aromatic alkynes, paraformaldehyde, and a Lewis acid catalyzed reaction at room temperature. This reaction is metal-free and atom-economic. Single crystals of two typical 1,3-dioxane derivatives are obtained. A mechanism that the reaction proceeds through a six- or eight-membered ring intermediate is proposed.
- Subjects :
- Organic Chemistry
Subjects
Details
- ISSN :
- 14372096 and 09365214
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Synlett
- Accession number :
- edsair.doi...........229238ada4aa2644249e7de0fd2448c8