RETROSPECTIVE ANALYSIS OF EPIDEMIOLOGY, PROGNOSTIC FACTORS AND RESPONSE OF TREATMENT OF RECTAL CANCER

Background Rectal cancers have always been considered as a part of CRCs in related epidemiological studies, it’s one of the major public health problems. Rectal cancers are the second most common (28%) cancers in large intestine after proximal colon cancers (42%).Colorectal cancer is the third most frequently diagnosed malignancy just behind lung and breast cancer, accounting for about 1.8 million cases each year, and the second cancer causing death worldwide, accounting to more than 850,000 deaths per year. Objective To evaluate the clinico-epidemiological factors in rectal cancer patients with response to treatment, duration of response and overall survival outcome. Methods This is a retrospective study which enrolled 60 patients diagnosed with rectal cancer treated at Clinical Oncology and Nuclear Medicine Department at AinShams University Hospitals in the period between January 2012 and December 2015. Data collected from the files of Ain Shams University. Results Among the studied population enrolled in our study, we found that major factors affected both OS & DFS were ECOGPS,histopathological differentiation, pathological staging, CRM, LVSI, PNI. While factors affected OS only with no impact on DFS were gender variant, clinical T & N stage, ECE and there is statistical significance in DFS and the tumor site. The median of overall, disease-free and progression free survival of all studied population were 37, 29 and 9 months respectively. Conclusion The fact that identified epidemiological and prognostic factors for disease free and overall survival in rectal cancer were not novel, this work reflect real life management of care and outcomes of rectal cancer patients.