Insilico Binding Studies of Resveratrol for Protective Effects in Neurodegeneration Using Glutamate Receptor 3B as Target Model

Resveratrol, a phytoalexin phenolic compound found in different plants, like berries, grapes, and peanuts and studied on defensive mechanisms of neurodegeneration. Glutamate receptors are synaptic receptors, which are situated on the films of neuronal cells. Glutamate is utilized to gather proteins, however, it additionally works as a neurotransmitter and is especially copious in the sensory system. NMDA receptor 3B utilized clinically as a part of the treatment of AD and in this way it offers a fantastic apparatus to encourage translational extrapolation. In this work, we have demonstrated a three-dimensional structure for glutamate [NMDA] receptor 3B subunit utilizing MODELLER9V7 programming with 2RCA as layout. With the guide of molecular elements and molecular recreations, it was distinguished that the created structure was dependable. This structure was utilized to recognize better inhibitor utilizing docking with Resveratrol. The Resveratrol was docked to the glutamate receptor 3B structure into the dynamic site containing deposits, for example, ASP21, LEU30, TYR31, HIS59, and MET60. Our test studies can be further used to build up a superior medication for Alzheimer’s disease.