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Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs
- Source :
- Pharmaceutical Chemistry Journal. 51:533-539
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.
- Subjects :
- 0301 basic medicine
Pharmacology
Purine
Chlorpropamide
010405 organic chemistry
Chemistry
Pharmacology toxicology
01 natural sciences
0104 chemical sciences
03 medical and health sciences
chemistry.chemical_compound
Glycogen phosphorylase
030104 developmental biology
Biochemistry
Drug Discovery
medicine
Hypoglycemic Effects
Purine derivative
Vildagliptin
Protein glycation
medicine.drug
Subjects
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........21f58eb952ed4f0cd94f2be9911204a0