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Radiation Effects on Cold-Induced Growth Response of Interscapular Brown Fat

Authors :
John F. Thomson
Karen L. Beetham
Sharron L. Nance
Source :
Radiation Research. 38:55
Publication Year :
1969
Publisher :
JSTOR, 1969.

Abstract

When rats are transferred to a 5°C environment immediately after exposure to 400 R of x-irradiation, the rate of growth of interscapular brown fat is significantly inhibited, in comparison with that in pair-fed unirradiated cold-exposed controls. The most striking effect is on the early hyperplasia of the tissue, which in the controls is maximal after 3 days in the cold. After 3 weeks, the mass of interscapular brown fat in the irradiated animals is only slightly less than that in control rats, but the total amounts of various components of the tissue (total nitrogen, nucleic acids, phospholipids, respiratory enzymes) remain below the control level for at least 5 weeks. It seems unlikely that decreased thermogenic activity is of major importance in reducing the survival of cold-exposed irradiated rats.

Details

ISSN :
00337587
Volume :
38
Database :
OpenAIRE
Journal :
Radiation Research
Accession number :
edsair.doi...........21d6074665414468214e3670ecc6da01
Full Text :
https://doi.org/10.2307/3572710