Detection of Adducts Formed upon Treatment of DNA with Cisplatin and Carboplatin

Since the discovery of the antitumor activity of cis-diamminedichloroplatinum(II) (cisplatin), it is generally accepted that the cytotoxic action of platinum drugs is the consequence of their interaction with cellular DNA. Therefore, knowledge about the formation and persistence of DNA damage may help to understand the working mechanism of these compounds and may eventually lead to the development of better Pt-containing antitumor drugs.