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Enhanced surface hydrophilicity of polylactic acid sutures treated by lipase and chitosan
- Source :
- Textile Research Journal. 89:3291-3302
- Publication Year :
- 2018
- Publisher :
- SAGE Publications, 2018.
-
Abstract
- Polylactic acid (PLA) surgical sutures are a new type of absorbable sutures that can be degraded and absorbed in the body. However, there is high hydrophobicity for the surface of PLA sutures, which leads to poor biocompatibility and cellular affinity. In order to increase the hydrophilicity, the PLA sutures were etched by lipase firstly, and then grafted with chitosan. The results indicate that the optimal conditions of treating PLA sutures by lipase were as follows: 45℃ reaction temperature, 4.5 g/L concentration of lipase and 8 h reaction time. The sutures were etched by lipase and then formed some grooves and a number of hydroxyl (-OH) bonds, which led to increased surface area and hydrophilicity, but a drop in mass and strength. The optimal conditions of grafting chitosan onto PLA sutures were as follows: 4 h reaction time and 3 g/L concentration of chitosan. The chitosan grafted and loaded on the surface of PLA sutures, and in some areas of the sutures the chitosan reunited, which led to a rough surface and large friction coefficient. Finally, the hydrophilicity of the PLA sutures, treated by lipase and then grafted with chitosan, was greatly improved.
- Subjects :
- 010302 applied physics
Polymers and Plastics
biology
Absorbable suture
technology, industry, and agriculture
macromolecular substances
02 engineering and technology
equipment and supplies
021001 nanoscience & nanotechnology
01 natural sciences
Chitosan
chemistry.chemical_compound
stomatognathic system
Polylactic acid
chemistry
0103 physical sciences
biology.protein
Chemical Engineering (miscellaneous)
Lipase
Absorbable sutures
0210 nano-technology
Biomedical engineering
Subjects
Details
- ISSN :
- 17467748 and 00405175
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Textile Research Journal
- Accession number :
- edsair.doi...........21963aa632933cf4b3533dede4d089cd