Direct Crystal to Glass Transformations of Trehalose Induced by Milling, Dehydration and Annealing

In this paper, we present a short review of the different solid state vitrification routes of trehalose recently identified by our group. Three routes are investigated: the mechanical milling of the stable crystalline anhydrous form, the rapid dehydration of the dihydrate form, and the sub Tg annealing of the polymorphic form α. The investigations have been performed by powder x‐ray diffraction and differential scanning calorimetry.