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Cancer Stem Cell Markers: Classification and Their Significance in Cancer Stem Cells
- Source :
- Bioengineering and Cancer Stem Cell Concept ISBN: 9783319256689
- Publication Year :
- 2015
- Publisher :
- Springer International Publishing, 2015.
-
Abstract
- This chapter is dealing with identification of cancer stem cell markers, their latest classification, function in normal and cancer stem cells (CSCs), and their use in development of novel targeted antitumor therapy. It was difficult to prove the CSCs existence, unless the in vivo and in vitro experiments have been done supporting the theory that they have common clonogenic origin and perpetuate always the same phenotypic marker(s) on their surface, being also able to induce production of original tumor in transplanted NOD/SCID mice. The cancer stem cells so far have been found in most of human tissues and checked as well, in agar, for anchorage growth. Today they can be isolated using magnetic beads coated with antibodies targeted against specific markers.
Details
- ISBN :
- 978-3-319-25668-9
- ISBNs :
- 9783319256689
- Database :
- OpenAIRE
- Journal :
- Bioengineering and Cancer Stem Cell Concept ISBN: 9783319256689
- Accession number :
- edsair.doi...........214118ea1a24770e34d6a234605a1b75
- Full Text :
- https://doi.org/10.1007/978-3-319-25670-2_4