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Cancer Stem Cell Markers: Classification and Their Significance in Cancer Stem Cells

Authors :
Mirjana Pavlovic
Bela Balint
Source :
Bioengineering and Cancer Stem Cell Concept ISBN: 9783319256689
Publication Year :
2015
Publisher :
Springer International Publishing, 2015.

Abstract

This chapter is dealing with identification of cancer stem cell markers, their latest classification, function in normal and cancer stem cells (CSCs), and their use in development of novel targeted antitumor therapy. It was difficult to prove the CSCs existence, unless the in vivo and in vitro experiments have been done supporting the theory that they have common clonogenic origin and perpetuate always the same phenotypic marker(s) on their surface, being also able to induce production of original tumor in transplanted NOD/SCID mice. The cancer stem cells so far have been found in most of human tissues and checked as well, in agar, for anchorage growth. Today they can be isolated using magnetic beads coated with antibodies targeted against specific markers.

Details

ISBN :
978-3-319-25668-9
ISBNs :
9783319256689
Database :
OpenAIRE
Journal :
Bioengineering and Cancer Stem Cell Concept ISBN: 9783319256689
Accession number :
edsair.doi...........214118ea1a24770e34d6a234605a1b75
Full Text :
https://doi.org/10.1007/978-3-319-25670-2_4