A General Kilogram Scale Protocol for Suzuki–Miyaura Cross-Coupling in Water with TPGS-750-M Surfactant

Authors :: Markus Baenziger
Michael Parmentier
Audrey Langlois
Mona K. Wagner
Fabrice Gallou
Regina Wickendick
Source :: Organic Process Research & Development. 24:1536-1542
Publication Year :: 2020
Publisher :: American Chemical Society (ACS), 2020.
Abstract: The development of a kilogram scale protocol for a Suzuki–Miyaura cross-coupling step toward the synthesis of the drug candidate LSZ102 is described. Particularly, the use of the surfactant TPGS-75...

Subjects :: Coupling
Kilogram
Scale (ratio)
010405 organic chemistry
Drug candidate
Chemistry
Organic Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
Micelle
0104 chemical sciences
Pulmonary surfactant
Physical and Theoretical Chemistry

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