Do cystic fibrosis centres with the lowest FEV1 still use the least amount of intravenous antibiotics? A registry-based comparison of intravenous antibiotic use among adult CF centres in the UK

Background The Epidemiologic Study of Cystic Fibrosis using 1995–1996 and 2003–2005 data found that CF centres with lowest FEV 1 tended to use fewer intravenous antibiotics. We repeated the analyses using 2013–2014 UK CF registry data to determine if this was still the case. Methods Analysing data for 2013 and 2014 separately, 28 adult CF centres were ranked according to median % age-adjusted FEV 1 . The top 7 centres were placed in the ‘upper quarter' (best FEV 1 ), the bottom 7 centres in ‘lower quarter' (lowest FEV 1 ), and the rest in ‘middle half'. IV use was stratified according to %FEV 1 , then compared between the three groups. Results Centres in the ‘upper quarter' and ‘middle half' used significantly more IV antibiotics compared to centres in the ‘lower quarter' (van Elteren test P -value Conclusions CF centres with lowest FEV 1 are still distinguished by lower use of intravenous antibiotics.