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The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1
- Source :
- Tetrahedron Letters. 49:3276-3278
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2′.
Details
- ISSN :
- 00404039
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........207e7f4f979af96c16ad7c9d62aaf425
- Full Text :
- https://doi.org/10.1016/j.tetlet.2008.03.070