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The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

Authors :
Samuel Vorin
Guillaume Viault
Frédéric Caijo
Philippe Juin
Florence Manero
Vijay L. Manthati
Danielle Grée
René Grée
Source :
Tetrahedron Letters. 49:3276-3278
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2′.

Details

ISSN :
00404039
Volume :
49
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........207e7f4f979af96c16ad7c9d62aaf425
Full Text :
https://doi.org/10.1016/j.tetlet.2008.03.070