ChemInform Abstract: Activating Group Recycling in Action: A Rhodium-Catalyzed Carbothiolation Route to Substituted Isoquinolines

Authors :: Michael C. Willis
Milan Arambasic
Joel F. Hooper
Source :: ChemInform. 45
Publication Year :: 2014
Publisher :: Wiley, 2014.
Abstract: A new rhodium(I) catalyst allows practical and efficient alkyne carbothiolation reactions to be achieved on synthetically useful ketone-bearing aryl methyl sulfides. The carbothiolation adducts, featuring a ‘recycled methyl sulfide’ activating group, are convenient precursors to highly substituted isoquinolines.

Subjects :: chemistry.chemical_classification
chemistry.chemical_compound
chemistry
Group (periodic table)
Aryl
Alkyne
chemistry.chemical_element
General Medicine
Methyl sulfide
Medicinal chemistry
Catalysis
Adduct
Rhodium

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