Long-term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation

Hutter G, Nowak D, Mossner M, et al. N Engl J Med . 2009;360(7):692–698 PURPOSE OF THE STUDY. HIV infection of a target cell requires the expression of CD4 and a chemokine receptor. Early after HIV transmission, the chemokine coreceptor used most often is chemokine receptor 5 (CCR5). Approximately 1% of Northern European individuals possess homozygosity for a 32-base pair deletion (Δ32) in their CCR5 genes. These individuals are exceptionally resistant to HIV infection with CCR5-expressing HIV. The purpose of this study was to determine whether HIV could …