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Enantioselective Synthesis of Coumarins Catalyzed by Chiral Squaramide

Enantioselective Synthesis of Coumarins Catalyzed by Chiral Squaramide

Authors :
Zhiwei Ma
Zhijing Liu
Chuanchuan Wang
Degang Ding
Juntao Liu
Xiaopei Chen
Guangwei Geng
Source :
Letters in Organic Chemistry. 19:919-923
Publication Year :
2022
Publisher :
Bentham Science Publishers Ltd., 2022.

Abstract

Abstract: A newly chiral tertiary amine-squaramide has successfully developed and applied into the asymmetric Michael addition of 4-hydroxycoumarin to β,γ-unsaturated α-ketoesters. The catalyst system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A series of coumarin derivatives were obtained with good yields and enantioselectivities.

Subjects

Subjects :
Organic Chemistry
Biochemistry

Details

ISSN :
15701786
Volume :
19
Database :
OpenAIRE
Journal :
Letters in Organic Chemistry
Accession number :
edsair.doi...........1f9710d67d67505d476ae62af4616a33
Full Text :
https://doi.org/10.2174/1570178619666220309155353