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Hypoxia, Lactate Accumulation, and Acidosis: Siblings or Accomplices Driving Tumor Progression and Resistance to Therapy?
- Source :
- Oxygen Transport to Tissue XXXV ISBN: 9781461472568
- Publication Year :
- 2013
- Publisher :
- Springer New York, 2013.
-
Abstract
- This chapter briefly summarizes the most important processes by which hypoxia, lactate accumulation, and acidosis may influence malignant progression and therapeutic resistance of solid malignant tumors. While these phenomena are often elements of an integrated reaction, they may occur independently of each other under certain circumstances. The latter information may be of interest with regard to possible “targeted” therapeutic interventions.
Details
- ISBN :
- 978-1-4614-7256-8
- ISBNs :
- 9781461472568
- Database :
- OpenAIRE
- Journal :
- Oxygen Transport to Tissue XXXV ISBN: 9781461472568
- Accession number :
- edsair.doi...........1f87c3ddf2aae43c5da399ca225ec947