Brain Renin-Angiotensin System: A Novel Therapeutic Target for Psychostimulant and Alcohol Related Disorders?

The renin angiotensin system (RAS) is involved not only in the regulation of blood pressure and fluid homeostasis, but also in the modulation of multiple additional functions in the brain. In this sense, it was found to be involved in many neuroadaptive responses induced by drugs such as cocaine, amphetamines, alcohol, as well as others.